Antibiotic Solid Potassium Acetate
CAS NO.: 127-08-2
Molecular Formula: CH3COOK
Molecular Weight: 98.14
Character: white crystal and it is easily soluble in water, acid and alcohol.
Usage: It is used as buffer agent, diuretic of Benzylpenicillin potassium, chemical reagent, industrial catalyst, auxiliaries, and also used in snow & ice melting agent, fertilizer and oilfield drilling.
Package: 25kg plastic woven bag or 1000kg Ton-bag
Storage: It should be stored in a dry and ventilative warehouse, kept away from heat and moisture during transportation, unloaded with care so as to avoid damage. Furthermore, it must be stored separately from poisonous substances.
- Product Description
Antibiotic Solid Potassium Acetate — Pharmaceutical-Grade Penicillin Intermediate with Consistent Batch Purity
Antibiotic Solid Potassium Acetate (CAS No. 127-08-2, CH₃COOK, MW: 98.14) is a high-purity white crystalline salt manufactured by Shanxi Zhaoyi Chemical Co., Ltd., a business that has been making acetate for more than 30 years, since 1988. The plant covers an area of 27,000 m2 with an annual capacity of 150,000 tonnes of output. It comprises 99% min CH3COOK 0.005% max chloride 0.0003% max iron and 0.0005% max heavy metals. This satisfies the stringent requirements of the pharmaceutical sector. It is used as a dependable medical raw material of potassium acetate in the production of antibiotics, buffering injectables and preparations for haemodialysis.
Technical Specifications
Parameter | Specification | Test Method |
Content (CH₃COOK) | ≥99.0% | Titration |
Water Insoluble Matter | Qualified | Visual inspection |
Basicity (as K₂CO₃) | ≤0.12% | Titration |
Acidity (as HA) | ≤0.05% | Titration |
Chloride (Cl) | ≤0.01% | Ion chromatography |
Sulfate (SO₄) | ≤0.02% | Gravimetric |
Iron (Fe) | ≤0.0005% | Spectrophotometry |
Heavy Metal (as Pb) | ≤0.0005% | Atomic absorption |
Potassium Permanganate Reducing | Qualified | Color comparison |
pH (5% Solution) | 7.5-9.0 | pH meter |
Molecular Weight | 98.14 g/mol | - |
CAS Number | 127-08-2 | - |
Appearance | White crystal | Visual |
What Is Antibiotic Solid Potassium Acetate?
The product is a white crystalline solid of pharmaceutical grade organic potassium salt. It is easily soluble in water, acids and alcohol making it very flexible in aqueous and solvent based pharmacological solutions.
It has crucial functional significance as a precipitating agent, pH buffer and source of potassium ions in the manufacture of antibiotics. Its controlled purity profile sets it apart from standard industrial-grade acetates — every parameter is engineered specifically around the sensitivity of pharmaceutical synthesis processes.
Key Product Characteristics
This product works well as a medicine because of its physical and chemical properties:
- Crystal form: solid white crystals with a uniform particle structure
- Solubility: It dissolves easily in water, acid, and alcohol, making it perfect for both water-based injection systems and solvent-based synthesis.
- Stable buffering: the pH of a 5% water solution stays between 7.5 and 9.0, which means that buffering works reliably in settings where antibiotics are made.
- Low moisture content: free water ≤0.1%, which keeps the product's structure while it's being stored and stops sensitive recipes from breaking down too quickly.
- Free acid control: free acid ≤0.03%, which lowers the chance of pH changes that could damage beta-lactam ring structures while reconstituted or stored.
These properties make it a reliable potassium acetate penicillin intermediary for pharmaceutical procurement groups seeking proven uniformity batch after batch.
Pharmaceutical Applications
Penicillin G Potassium Synthesis
As the main precipitating agent, this substance makes benzylpenicillin potassium, also known as Penicillin G Potassium. This causes potassium ions to be added to the penicillin molecule in butyl acetate or a similar solvent. This causes the molecule to crystallise quickly and make a lot of product. Metallic impurities are strictly controlled (iron 0.0003%, heavy metals 0.0005%), so you can get clean crystallisation without losing the antibiotic's effectiveness or having to do a lot of cleaning further down the line.
Pharmaceutical Buffering for Injection
Stability of pH is a must for parenteral drug formulations. This substance keeps the chemical stability of antibiotic solutions after they are reconstituted by regulating the pH and acting as an electrolyte. Its narrow pH range for free acids and buffering acids directly stops acid from breaking down the beta-lactam ring structure while it is being stored and given intravenously.
Making the haemodialysis solution
It is potassium acetate of the medicinal grade for dialysate concentrates and provides a steady flow of acetate ions. The liver breaks down acetate, which is a bicarbonate precursor. Because of this, it is very important that the potassium level is accurate and that it is free of pyrogens and organic pollutants.
Antibiotic Solid Potassium Acetate vs Other Products
Feature | Our Pharma Grade | Standard Industrial Grade | Competitor Pharma Grade |
Purity (CH₃COOK) | ≥99.0% | 95-98% | 98.5-99.0% |
Heavy Metals (Pb) | ≤0.0005% | ≤0.003% | ≤0.001% |
Chloride Content | ≤0.01% | ≤0.05% | ≤0.02% |
Batch Consistency | ±0.1% variation | ±0.5% variation | ±0.2% variation |
pH Stability | 7.5-9.0 | 7.0-10.0 | 7.5-9.5 |
Dissolution Time | <3 minutes | <10 minutes | <5 minutes |
Certifications | ISO/KOSHER/HALAL | ISO only | ISO/HALAL |
Technical Support | Dedicated team | Limited | Basic |
Supply Capacity | 150,000 tons/year | Varies | 50,000 tons/year |
Lead Time | 7-14 days | 21-30 days | 14-21 days |
Quality Control & Documentation
Every batch of Antibiotic Solid Potassium Acetate produced at our facility undergoes rigorous quality verification aligned with pharmaceutical industry standards. Quality documentation provided includes:
- Certificate of Analysis (COA) — issued per batch with full parameter testing results
- MSDS / SDS — available in multiple languages to support international regulatory requirements
- Third-party testing support — SGS and other accredited laboratories accepted
- Customer-specific test reports — available for bulk pharmaceutical buyers
Our stable upstream raw material supply chain and documented quality management processes reduce batch variation and support your internal supplier qualification audits.
Certifications & Compliance
Shanxi Zhaoyi Chemical Co., Ltd. maintains internationally recognized certifications that support pharmaceutical and food-grade supply chain requirements:
- ISO 9001 — Quality Management System
- ISO 14001 — Environmental Management System
- ISO 45001 — Occupational Health and Safety Management System
Kosher Certification
Halal Certification (for applicable product grades)
On-site factory audits by customers from all over the world are fully supported. You can get compliance documentation in multiple languages to make the process of approving suppliers go more quickly.
Packaging & Storage
Item | Details |
Packaging Options | 25 kg plastic woven bag / 1,000 kg ton bag |
Storage Conditions | Dry, well-ventilated warehouse; away from heat and moisture |
Handling | Handle with care to avoid packaging damage |
Segregation | Must be stored separately from toxic substances |
The low free water content (≤0.1%) and crystallinity of the product are directly maintained by good storage. This protects both the test value and the way the product dissolves in your manufacturing processes.
Why Industry Pain Points Make Supplier Selection Critical
Many pharmaceutical manufacturers have experienced quality failures when sourcing from suppliers who lack pharmaceutical manufacturing discipline. Common problems include:
- Substandard purity leading to low antibiotic yield and difficult downstream purification
- Batch-to-batch variation causing inconsistent synthesis outcomes
- Poor buffering performance causing pH fluctuations that reduce reaction efficiency
- Incompatible impurity profiles generating unwanted by-products
- Suppliers unable to provide technical application support
These issues cost time, material, and regulatory confidence. Shanxi Zhaoyi Chemical Co., Ltd. addresses each of these directly — through verified specification controls, stable production processes, and dedicated technical consultation available 24/7.
Our Exhibitions
FAQ
Q: What about this item makes it a good potassium acetate penicillin intermediate?
A: It is very pure, with less than 1% arsenic and less than 0.0001% heavy metals. This means that it provides clean potassium ions during crystallisation without adding any impurities that could make antibiotics less effective or make the purification process more difficult.
Q: What's the point of specifying the pH for making antibiotics?
A: a 5% water solution with a pH range of 7.5 to 9.0 and steady, predictable buffering. This keeps the pH from changing, which could hurt the beta-lactam structures during production or storage and make the process less effective.
Q: Can you give me a COA that is specific to my batch and help with third-party testing?
A: Yes. For every batch of products made, a full COA is sent out, and third-party testing through SGS or customer-designated laboratories is fully supported.
Q: What kinds of packaging options are there for people who buy drugs in bulk?
A: standard way to package things is in 25 kg woven plastic bags or 1,000 kg pallet bags. Based on your needs, we can set up custom package designs and OEM labelling.
Q: What's the usual lead time and smallest amount I can order?
A: The usual lead time is between 5 and 7 business days. For orders that are already in stock, shipping can be set up within 24 hours. For current stock supply and MOQ for your goal number, please contact us directly.
Q: Does Shanxi Zhaoyi Chemical allow seller checks to happen on-site?
A: Yes. International and domestic customers can do full on-site factory audits that include reviewing documentation, inspecting production lines, and making sure that the quality system is in line with your supplier qualification procedures.
Contact Us
Reach our technical and sales team at sxzy@sxzhaoyi.com — responses within 2 hours for standard inquiries regarding Antibiotic Solid Potassium Acetate.
USER EVALUATE
Here is the customer's evaluation of us